Jakridari Lauha; Uses/ Indications, Dosage, Side Effects

Jakridari Lauha (JDL) an Ayurvedic preparation used as a traditional medicine in the treatment of hepatic diseases in the rural population. To find out the toxicological characteristic of JDL, it was administered chronically to the male rats at a dose of 400 mg/kg. After 45 days chronic administration of the JDL preparation the following toxicological changes were noted. All throughout the experimental period the JDL treated animals were always maintaining gradual fall in body weight. From Day 33 to Day 45 the loss in body weight varied between 4.97 % to as high as 8.32%. None of these changes in body weights of the JDL treated rats for the total of 45 days were statistically significantly different from their corresponding body weights of the control animal. The study also involved post-mortem comparison of the relative weights of major organs and water content within the various tissues of the drug-treated rats to those of the control group animals. There is a statistically insignificant (p=0.565) [3.945867 %] decrease in the relative percent weight of the male rat heart. There is a statistically significant (p=0.028) decrease in the organ water content of the male rat heart. [7.651798% decrease]. There is a statistically insignificant (p=0.692) [2.789 %] increase in the relative percent weight of the male rat lungs. There is a statistically insignificant (p=0.510) [1.773111 %] decrease in the organ water content of the male rat lungs. There is a [8.44545 %] decrease in the relative percent weight of the male rat liver, the decrease though not significant yet it was prominent (p=0.353). There is an [4.27998 %] increase in the organ water content of the male rat liver, the increase though not significant yet it was prominent (p=0.250). There is a [9.791237 %] decrease in the relative percent weight of the male rat kidney, the decrease though not significant yet it was prominent (p=0.158). There is a [3.67856 %] decrease in the organ water content of the male rat kidney, the decrease though not significant yet it was noticeable (p=0.054). There is a negligible [2.27011 %] increase in the relative percent weight of the male rat spleen, which was statistically not at all significant (p=0.782). There is a [7.370657 %] decrease in the organ water content of the male rat spleen, the decrease though not significant yet it was prominent (p=0.113). There is a statistically insignificant (p=0.545) [8.058056 %] decrease in the relative percent weight of the male rat thymus. There is a negligible [1.985381 %] decrease in the relative percent weight of the rat testis, which was statistically not at all significant (p=0.804). There is a statistically insignificant (p=0.596) [0.940588 %] decrease in the organ water content of the rat testis.

References

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Jakridari Lauha

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